Contrasting Networks for Recognition Memory and Recency Memory Revealed by Immediate-Early Gene Imaging in the Rat.
The expression of the immediate-early gene c-fos was used to compare networks of activity associated with recency memory (temporal order memory) and recognition memory. In Experiment 1, rats were first familiarized with sets of objects and then given pairs of different, familiar objects to explore....
| Publicado en: | Behavioral Neuroscience Vol. 128; no. 4; pp. 504 - 523 |
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| Autores principales: | , , , |
| Formato: | Artículo |
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American Psychological Association
Aug2014
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=97347940&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 97347940 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: Aug2014 vid: 128 iid: 4 pid: 34 pub: American Psychological Association artinfo: ui: 97347940 10.1037/a0037055 ppf: 504 ppct: 19 formats: tig: atl: Contrasting Networks for Recognition Memory and Recency Memory Revealed by Immediate-Early Gene Imaging in the Rat. aug: au: Olarte-Sánchez, Cristian M. Kinnavane, Lisa Amin, Eman Aggleton, John P. affil: Cardiff University su: Memory Gene expression in mammals Laboratory rats Entorhinal cortex Dentate gyrus Hippocampus (Brain) Object recognition algorithms sug: subj: Memory All Other Animal Production Gene expression in mammals Laboratory rats Entorhinal cortex Dentate gyrus Hippocampus (Brain) Object recognition algorithms keyword: immediate-early genes network models rat recency memory recognition memory immediate-early genes network models rat recency memory recognition memory ab: The expression of the immediate-early gene c-fos was used to compare networks of activity associated with recency memory (temporal order memory) and recognition memory. In Experiment 1, rats were first familiarized with sets of objects and then given pairs of different, familiar objects to explore. For the recency test group, each object in a pair was separated by 110 min in the time between their previous presentations. For the recency control test, each object in a pair was separated by less than a 1 min between their prior presentations. Temporal discrimination of the objects correlated with c-fos activity in the recency test group in several sites, including area Te2, the perirhinal cortex, lateral entorhinal cortex, as well as the dentate gyrus, hippocampal fields CA3 and CA 1. For both the test and control conditions, network models were derived using structural equation modeling. The recency test model emphasized serial connections from the perirhinal cortex to lateral entorhinal cortex and then to the CAI subfield. The recency control condition involved more parallel pathways, but again highlighted CAI within the hippocampus. Both models contrasted with those derived from tests of object recognition (Experiment 2), because stimulus novelty was associated with pathways from the perirhinal cortex to lateral entorhinal cortex that then involved both the dentate gyrus (and CA3) and CAI in parallel. The present findings implicate CAI for the processing of familiar stimuli, including recency discriminations, while the dentate gyrus and CA3 pathways are recruited when the perirhinal cortex signals novel stimuli. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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