Extended-spectrum β-lactamase-producing bacteria causing community-acquired urinary tract infections in children.
Background: Extended-spectrum β-lactamase (ESBL)-producing bacteria are infrequent pathogens of community-acquired (CA) urinary tract infections (UTIs) in children. The aim of this study was to assess the frequency of and identify risk factors for CA-UTIs due to ESBL-producing microorganisms (CA-ESB...
| Publicado en: | Pediatric Nephrology Vol. 29; no. 9; pp. 1583 - 1588 |
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| Autor principal: | |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=97680190&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 97680190 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Sep2014 vid: 29 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 97680190 103881133 103881133 10.1007/s00467-014-2810-y 97680190 ppf: 1583 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Extended-spectrum β-lactamase-producing bacteria causing community-acquired urinary tract infections in children. aug: au: Megged, Orli affil: Pediatric Department and Infectious Diseases Unit, Shaare Zedek Medical Center affiliated with Hebrew University-Hadassah School of Medicine, Jerusalem Israel sug: subj: Urinary Tract Infections Microbiology Community-Acquired Infections Microbiology Urinary Tract Infections Epidemiology Community-Acquired Infections Epidemiology Human Arabs Descriptive Statistics Length of Stay Multivariate Analysis Odds Ratio Confidence Intervals Risk Factors Incidence Israel Academic Medical Centers Data Analysis Software Fisher's Exact Test T-Tests Logistic Regression Antibiotics Therapeutic Use Infant Child, Preschool Child Infant, Newborn Male Female Urinary Tract Infections Drug Therapy Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Infant, Newborn: birth-1 month Male Female ab: Background: Extended-spectrum β-lactamase (ESBL)-producing bacteria are infrequent pathogens of community-acquired (CA) urinary tract infections (UTIs) in children. The aim of this study was to assess the frequency of and identify risk factors for CA-UTIs due to ESBL-producing microorganisms (CA-ESBL-UTI). Methods: The medical records of all children diagnosed with CA-ESBL-UTI at our medical center between 2003 and 2013 were reviewed. Patients with non-ESBL-UTIs during the same period were included as controls. Results: Eighty cases of CA-ESBL-UTI were identified. The incidence of ESBL-UTI increased from 2 to 3.8% during the study period. Compared to children with non-ESBL-UTI, those with ESBL were more likely to be of Arab descent, to have underlying medical conditions, to have received antibiotics in the month prior to the UTI and to have been previously hospitalized. The mean duration of hospitalization for patients with an ESBL-UTI was significantly longer than that for patients with a non-ESBL UTI (3.6 vs. 2 days; P = 0.01). In multivariate analysis, Arab ethnicity [odds ratio (OR) 6.1; 95 % confidence interval (CI) 2.7-13.6] and recent antibiotic treatment (OR 4.0; 95 % CI 1.6-10.4) were risk factors for CA-ESBL-UTI. Conclusions: The incidence of CA-ESBL-UTI is rising. The empiric treatment for suspected UTI in children who had been previously hospitalized and who had received antibiotics in the last month should cover ESBL-producing bacteria. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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