A Comparison between Moderate- and High-dose Furazolidone in Triple Regimens for Helicobacter pylori Eradication in Iran.
BACKGROUND Furazolidone has been used as an alternative for clarithromycin or metronidazole in Helicobacter pylori (H.pylori) eradication regimens. In Iran, 14-day Furazolidone-containing quadruple regimens have shown promising eradication rates, but short-course, low dose therapies are always attra...
| Publicado en: | Middle East Journal of Digestive Diseases Vol. 6; no. 4; pp. 1 - 9 |
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| Autores principales: | , , , , , , , |
| Formato: | equations & formulas research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Iranian Association of Gastroenterology & Hepatology
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=97921977&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 97921977 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085230 BG4K jtl: Middle East Journal of Digestive Diseases issn: 20085230 maglogo: N pubinfo: dt: 2014 vid: 6 iid: 4 pid: 70725 pub: Iranian Association of Gastroenterology & Hepatology artinfo: ui: 97921977 97921977 103889698 97921977 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: A Comparison between Moderate- and High-dose Furazolidone in Triple Regimens for Helicobacter pylori Eradication in Iran. aug: au: Hosseini, Vahid Mokhtare, Marjan Gholami, Mohsen Taghvaei, Tarang Maleki, Iradj Valizadeh, Mohammad Bari, Zohreh Fakheri, Hafez affil: Inflammatory Diseases of the Upper Gastrointestinal Tract Research Center, Mazandaran University of Medical Sciences, Sari, Iran sug: subj: Nitrofurans Classification Helicobacter Infections Drug Therapy Helicobacter Infections Prevention and Control Disease Eradication Evaluation Human Comparative Studies Iran Helicobacter Pylori Randomized Controlled Trials Data Analysis Software Chi Square Test ab: BACKGROUND Furazolidone has been used as an alternative for clarithromycin or metronidazole in Helicobacter pylori (H.pylori) eradication regimens. In Iran, 14-day Furazolidone-containing quadruple regimens have shown promising eradication rates, but short-course, low dose therapies are always attractive. Therefore, we designed a study to compare the efficacy of two 10-day triple regimens containing moderate and high dose furazolidone for H.pylori eradication. METHODS Two hundred and ten patients with peptic ulcer disease who were naïve to H.pylori treatment were included. They were randomized into 2 groups: 105 patients received omeprazole 20mg, amoxicillin 1000mg, and furazolidone 200mg(OAF-400), all twice a day for ten days. And the remaining 105 patients received omeprazole 20mg twice a day, amoxicillin 1000mg twice a day and furazolidone 200mg three times a day for ten days(OAF-600). Urease breath test was performed 8 weeks after the treatment to confirm H. pylori eradication. RESULTS The intention-to-treat eradication rate was 76.19% in group OAF-400 and 80.95% in group OAF-600 (p=0.38). Per protocol eradication rates were 81.63% and 89.47%, respectively (p= 0.11).Severe adverse effects were reported by 8.6% of the patients in group OAF-400 and 5.7% of the patient in group OAF-600 (p=0.1). However, the total side effects (including mild, moderate, and severe ones) were significantly more prevalent in the OAF-600 group (p=0.001). CONCLUSION None of our triple furazolidone-based regimens (moderate- and high-dose) could achieve the standard eradication rate, and therefore, cannot be considered as a suitable option for first-line treatment. pubtype: Academic Journal doctype: equations & formulas research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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