Three-Component Coupling Based on Flash Chemistry. Carbolithiation of Benzyne with Functionalized Aryllithiums Followed by Reactions with Electrophiles.

A flow microreactor method for three-component coupling of benzyne was developed based on flash chemistry. o-Bromophenyllithium generated from 1- bromo-2-iodobenzene and a functionalized aryllithium generated from the corresponding aryl halide were mixed at —70 °C. In the subsequent reactor o-bromop...

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Publicado en:	Journal of the American Chemical Society Vol. 136; no. 35; pp. 12245 - 12249
Autores principales:	Aiichiro Nagaki, Daisuke Ichinari, Jun-ichi Yoshida
Formato:	Artículo
Publicado:	American Chemical Society 9/3/2014
Materias:	Benzynes Electrophiles Microreactors Aryl halides Chemical decomposition Biogeochemical residence time Chemical reactions
Acceso en línea:	Ver este registro en EBSCOhost