New antimicrobial pregnane glycosides from the stem of Ecdysanthera rosea.
Phytochemical investigation on the stem of Ecdysanthera rosea led to the isolation of eight new C-21 pregnane glycoside ecdysosides A–H ( 1 – 8 ), together with one known pregnane glycoside ecdysantheroside A ( 9 ). Their structures were elucidated based on extensive spectroscopic data (MS, IR, 1D a...
| Publicado en: | Fitoterapia Vol. 99; pp. 267 - 276 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
Dec2014
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=99919208&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 99919208 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Dec2014 vid: 99 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 99919208 103925018 10.1016/j.fitote.2014.10.008 99919208 ppf: 267 ppct: 9 formats: tig: atl: New antimicrobial pregnane glycosides from the stem of Ecdysanthera rosea. aug: au: Song, Chang-Wei Lunga, Paul-Keilah Qin, Xu-Jie Cheng, Gui-Guang Gu, Jian-Long Liu, Ya-Ping Luo, Xiao-Dong affil: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China sug: subj: Plants, Medicinal Plant Stems Plant Extracts Analysis Plant Extracts Pharmacodynamics Antiinfective Agents Pharmacodynamics Glycosides Analysis Alternative Therapies In Vitro Studies Microbial Culture and Sensitivity Tests Magnetic Resonance Spectroscopy Mass Spectrometry Enterococcus Cryptococcus Dose-Response Relationship, Drug Descriptive Statistics Chemistry, Physical ab: Phytochemical investigation on the stem of Ecdysanthera rosea led to the isolation of eight new C-21 pregnane glycoside ecdysosides A–H ( 1 – 8 ), together with one known pregnane glycoside ecdysantheroside A ( 9 ). Their structures were elucidated based on extensive spectroscopic data (MS, IR, 1D and 2D NMR) analysis, as well as comparison with the reported literature data. Antimicrobial activities of all the compounds were evaluated against bacteria and yeasts. Compounds 1 , 9 , 3 and 5 exhibited moderate antibacterial activities against respective Enterococcus faecalis and Providensia smartii , with MIC value of 12.5 μg/mL. Compound 8 showed significant anti-yeast activity against Cryptococcus neoformans with MIC value of 12.5 μg/mL. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|