Catalytic Enantioselective Intermolecular Desymmetrization of Azetidines.

The first catalytic asymmetric desymmetrization of azetidines is disclosed. Despite the low propensity of azetidine ring opening and challenging stereocontrol, smooth intermolecular reactions were realized with excellent efficiency and enantioselectivity. These were enabled by the suitable combinati...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 137; no. 18; pp. 5895 - 5899
Main Authors:	Zhaobin Wang, Fu Kit Sheong, Sung, Herman H. Y., Williams, Ian D., Zhenyang Lin, Jianwei Sun
Format:	Article
Published:	American Chemical Society 5/13/2015
Subjects:	Enantioselective catalysis Azetidine Density functional theory Curtin-Hammett principle Amine derivatives
Online Access:	View this record in EBSCOhost