The role of DCDC2 genetic variants and low socioeconomic status in vulnerability to attention problems.
Both genetic and socio-demographic factors influence the risk for behavioral problems in the developmental age. Genetic studies indicate that shared genetic factors partially contribute to behavioral and learning problems, in particular reading disabilities (RD). For the first time, we explore the c...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 24; no. 3; pp. 309 - 319 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103768191&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103768191 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Mar2015 vid: 24 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103768191 101364038 10.1007/s00787-014-0580-5 NLM25012462 103768191 ppf: 309 ppct: 10 formats: fmt: @attributes: type: P tig: atl: The role of DCDC2 genetic variants and low socioeconomic status in vulnerability to attention problems. aug: au: Riva, Valentina Marino, Cecilia Giorda, Roberto Molteni, Massimo Nobile, Maria affil: Child Psychopathology Unit, Scientific Institute 'Eugenio Medea', Don L. Monza 20 23842 Bosisio Parini Italy sug: subj: Child Behavior Disorders Risk Factors Attention Socioeconomic Factors Child Behavior Disorders Familial and Genetic Italy Human Male Female Child Adolescence Child Behavior Checklist Checklists Descriptive Statistics Clinical Assessment Tools DNA Analysis Data Analysis Software Models, Statistical Analysis of Variance Pearson's Correlation Coefficient Chi Square Test Multivariate Analysis of Variance Post Hoc Analysis Genotype Multivariate Analysis of Covariance Funding Source Child: 6-12 years Adolescent: 13-18 years Male Female ab: Both genetic and socio-demographic factors influence the risk for behavioral problems in the developmental age. Genetic studies indicate that shared genetic factors partially contribute to behavioral and learning problems, in particular reading disabilities (RD). For the first time, we explore the conjoint role of DCDC2 gene, an identified RD candidate gene, and socioeconomic status (SES) upon behavioral phenotypes in a general population of Italian children. Two of the most replicated DCDC2 markers [i.e., regulatory element associated with dyslexia 1 (READ1), rs793862] were genotyped in 631 children (boys = 314; girls = 317) aged 11-14 years belonging to a community-based sample. Main and interactive effects were tested by MANOVA for each combination of DCDC2 genotypes and socioeconomic status upon emotional and behavioral phenotypes, assessed by Child Behavior Check-List/6-18. The two-way MANOVA (Bonferroni corrected p value = 0.01) revealed a trend toward significance of READ1(4) effect ( F = 2.39; p = 0.016), a significant main effect of SES ( F = 3.01; p = 0.003) and interactive effect of READ1(4) × SES ( F = 2.65; p = 0.007) upon behavioral measures, showing higher attention problems scores among subjects 'READ1(4+) and low SES' compared to all other groups ( p values range 0.00003-0.0004). ANOVAs stratified by gender confirmed main and interactive effects among girls, but not boys. Among children exposed to low socioeconomic level, READ1 genetic variant targets the worst outcome in children's attention. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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