Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers.
Purpose: The aim of the study was to determine the steady-state pharmacokinetics of metformin in healthy volunteers with different numbers of reduced-function alleles in the organic cation transporter 1 gene ( OCT1). Methods: The study was conducted as part of a randomized cross-over trial. Thirty-f...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 71; no. 6; pp. 691 - 698 |
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| Autores principales: | , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103797770&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103797770 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Jun2015 vid: 71 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103797770 102643862 10.1007/s00228-015-1853-8 NLM25939711 103797770 ppf: 691 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers. aug: au: Christensen, Mette Højlund, Kurt Hother-Nielsen, Ole Stage, Tore Damkier, Per Beck-Nielsen, Henning Brøsen, Kim affil: Department of Public Health, Clinical Pharmacology, University of Southern Denmark, J.B. Winsloews Vej 19 5000 Odense Denmark sug: subj: Metformin Pharmacokinetics Alleles Pharmacogenetics Genotype Funding Source Human Male Female Data Analysis Software Metformin Blood Metformin Urine Randomized Controlled Trials P-Value Glomerular Filtration Rate Kruskal-Wallis Test Descriptive Statistics Polymorphism, Genetic Male Female ab: Purpose: The aim of the study was to determine the steady-state pharmacokinetics of metformin in healthy volunteers with different numbers of reduced-function alleles in the organic cation transporter 1 gene ( OCT1). Methods: The study was conducted as part of a randomized cross-over trial. Thirty-four healthy volunteers with known OCT1 genotypes (12 with two wild-type alleles, 13 with one and 9 with two reduced-function alleles) were included. In one of the study periods, they were titrated to steady-state with 1 g metformin twice daily. Results: Neither AUC, C nor Cl were statistically significantly affected by the number of reduced-function alleles (0, 1 or 2) in OCT1: (AUC: 0, 1, 2: 14, 13 and 14 h ng/L ( P= 0.61)); ( C: 0, 1, 2: 2192, 1934 and 2233 ng/mL, ( P = 0.26)) and (Cl: 0, 1, 2: 31, 28 and 30 L/h ( P = 0.57)) Conclusions: In a cohort of healthy volunteers, we found no impact of different OCT1 genotypes on metformin steady-state pharmacokinetics. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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