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Genetic Variation in Melatonin Pathway Enzymes in Children with Autism Spectrum Disorder and Comorbid Sleep Onset Delay.

Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically unique...

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Published in:Journal of Autism & Developmental Disorders Vol. 45; no. 1; pp. 100 - 111
Main Authors: Veatch, Olivia, Pendergast, Julie, Allen, Melissa, Leu, Roberta, Johnson, Carl, Elsea, Sarah, Malow, Beth
Format: research Journal Article
Published: Springer Nature Jan2015
Online Access:View this record in EBSCOhost
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      dt: Jan2015
      vid: 45
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      pub: Springer Nature
      place: New York, New York
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        atl: Genetic Variation in Melatonin Pathway Enzymes in Children with Autism Spectrum Disorder and Comorbid Sleep Onset Delay.
      aug:
        au:
          Veatch, Olivia
          Pendergast, Julie
          Allen, Melissa
          Leu, Roberta
          Johnson, Carl
          Elsea, Sarah
          Malow, Beth
        affil: Sleep Disorders Division, Department of Neurology, Vanderbilt University Medical Center, 1161 21st Ave. S. Nashville 37232 USA
      sug:
        subj:
          Sleep Disorders Familial and Genetic
          Enzymes
          Melatonin
          Genes
          Human
          Comorbidity
          Genotype
          Child
          Autism Spectrum Disorder
          Experimental Studies
          Oxidoreductases
          Transferases
          Gene Expression
          Child: 6-12 years
      ab: Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically unique ASD subgroup, consisting solely of children with comorbid expression of sleep onset delay. We evaluated variation in two melatonin pathway genes, a cetylserotonin O- methyltransferase ( ASMT) and cytochrome P450 1A2 ( CYP1A2). We observed higher frequencies than currently reported ( p < 0.04) for variants evidenced to decrease ASMT expression and related to decreased CYP1A2 enzyme activity ( p ≤ 0.0007). We detected a relationship between genotypes in ASMT and CYP1A2 (r = 0.63). Our results indicate that expression of sleep onset delay relates to melatonin pathway genes.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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