Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers.
Purpose: Over-the-counter combinations containing acetaminophen and phenylephrine for treatment of the common cold and influenza are widespread, but there are few data about pharmacokinetics of these two drugs used in combination. We aimed to investigate pharmacokinetic interactions between acetamin...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 71; no. 2; pp. 151 - 159 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Feb2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103871934&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103871934 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Feb2015 vid: 71 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103871934 100372860 10.1007/s00228-014-1788-5 NLM25475358 103871934 ppf: 151 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers. aug: au: Atkinson, Hartley Stanescu, Ioana Salem, Isam Potts, Amanda Anderson, Brian affil: AFT Pharmaceuticals Ltd, Takapuna Auckland 0740 New Zealand sug: subj: Phenylephrine Administration and Dosage Phenylephrine Pharmacokinetics Biological Availability Acetaminophen Administration and Dosage Acetaminophen Pharmacokinetics Drug Interactions Human Randomized Controlled Trials Crossover Design Common Cold Drug Therapy Descriptive Statistics Confidence Intervals Jordan Ethnology Male Adolescence Adult Analysis of Variance Wilcoxon Signed Rank Test Funding Source Adolescent: 13-18 years Adult: 19-44 years Male ab: Purpose: Over-the-counter combinations containing acetaminophen and phenylephrine for treatment of the common cold and influenza are widespread, but there are few data about pharmacokinetics of these two drugs used in combination. We aimed to investigate pharmacokinetic interactions between acetaminophen and phenylephrine. Methods: A series of four randomised, open-label, crossover studies investigating phenylephrine and acetaminophen combination pharmacokinetics were undertaken ( n = 28, 30, 6 and 26) using standard non-compartmental analyses. Time-concentration observations from these four studies were pooled to examine the interaction between these two compounds. Data were analysed using non-linear mixed effects models. Results: Non-compartmental analyses showed an approximate doubling of phenylephrine plasma concentration when the standard 10-mg dose was administered in combination with acetaminophen. Population analysis was based on data from 90 subjects with 2050 observations. The relative bioavailability of phenylephrine 10 mg was doubled (Fbio 2.11, 95%CI 1.89, 2.31) when combined with acetaminophen 1000 mg, while the absorption half-time was reduced by 50 %. When combined with 500 mg of acetaminophen, bioavailability increased by 64 % (Fbio 1.64). Phenylephrine 5 mg in combination with acetaminophen 1000 mg produced a phenylephrine plasma time-concentration profile similar to that seen with phenylephrine 10 mg administered alone. Conclusions: The relative bioavailability of phenylephrine was increased when co-administered with acetaminophen. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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