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Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma.

Purpose: The aim of this study was to clarify the reliability of positron emission tomography (PET) using a new hypoxic cell tracer, 1-(2-[(18)F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole ((18)F-FRP170).Procedures: Twelve patients with glioblastoma underwent (18)F-FRP170 PET before tumor...

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Publicado en:Molecular Imaging & Biology Vol. 16; no. 1; pp. 127 - 136
Autores principales: Beppu, Takaaki, Terasaki, Kazunori, Sasaki, Toshiaki, Fujiwara, Shunrou, Matsuura, Hideki, Ogasawara, Kuniaki, Sera, Koichiro, Yamada, Noriyuki, Uesugi, Noriyuki, Sugai, Tamotsu, Kudo, Kohsuke, Sasaki, Makoto, Ehara, Shigeru, Iwata, Ren, Takai, Yoshihiro
Formato: research Journal Article
Publicado: Springer Nature Feb2014
Acceso en línea:Ver este registro en EBSCOhost
Sumario:Purpose: The aim of this study was to clarify the reliability of positron emission tomography (PET) using a new hypoxic cell tracer, 1-(2-[(18)F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole ((18)F-FRP170).Procedures: Twelve patients with glioblastoma underwent (18)F-FRP170 PET before tumor resection. Mean standardized uptake value (SUV) and normalized SUV were calculated at regions within a tumor showing high (high-uptake area) and relatively low (low-uptake area) accumulations of (18)F-FRP170. In these areas, intratumoral oxygen pressure (tpO2) was measured using microelectrodes during tumor resection.Results: Mean tpO2 was significantly lower in the high-uptake area than in the low-uptake area. A significant negative correlation was evident between normalized SUV and tpO2 in the high-uptake area.Conclusion: The present findings suggest that high accumulation on (18)F-FRP170 PET represents viable hypoxic tissues in glioblastoma.