Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma.
Purpose: The aim of this study was to clarify the reliability of positron emission tomography (PET) using a new hypoxic cell tracer, 1-(2-[(18)F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole ((18)F-FRP170).Procedures: Twelve patients with glioblastoma underwent (18)F-FRP170 PET before tumor...
| Publicado en: | Molecular Imaging & Biology Vol. 16; no. 1; pp. 127 - 136 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104004268&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104004268 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Feb2014 vid: 16 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104004268 104004268 NLM23873661 2012447065 10.1007/s11307-013-0670-7 NLM23873661 104004268 ppf: 127 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma. aug: au: Beppu, Takaaki Terasaki, Kazunori Sasaki, Toshiaki Fujiwara, Shunrou Matsuura, Hideki Ogasawara, Kuniaki Sera, Koichiro Yamada, Noriyuki Uesugi, Noriyuki Sugai, Tamotsu Kudo, Kohsuke Sasaki, Makoto Ehara, Shigeru Iwata, Ren Takai, Yoshihiro affil: Department of Neurosurgery, Iwate Medical University, Uchimaru 19-1, Morioka, 020-8505, Japan, tbeppu@iwate-med.ac.jp. sug: subj: Brain Neoplasms Radiography Fludeoxyglucose F 18 Pharmacokinetics Glioma Pathology Glioma Radiography Imidazoles Pharmacokinetics Oxygen Metabolism Tomography, Emission-Computed Adult Aged Aged, 80 and Over Brain Neoplasms Pathology Brain Neoplasms Surgery Cell Physiology Female Fludeoxyglucose F 18 Diagnostic Use Glioma Surgery Human Imidazoles Diagnostic Use Male Middle Age Pressure Proteins Metabolism Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Purpose: The aim of this study was to clarify the reliability of positron emission tomography (PET) using a new hypoxic cell tracer, 1-(2-[(18)F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole ((18)F-FRP170).Procedures: Twelve patients with glioblastoma underwent (18)F-FRP170 PET before tumor resection. Mean standardized uptake value (SUV) and normalized SUV were calculated at regions within a tumor showing high (high-uptake area) and relatively low (low-uptake area) accumulations of (18)F-FRP170. In these areas, intratumoral oxygen pressure (tpO2) was measured using microelectrodes during tumor resection.Results: Mean tpO2 was significantly lower in the high-uptake area than in the low-uptake area. A significant negative correlation was evident between normalized SUV and tpO2 in the high-uptake area.Conclusion: The present findings suggest that high accumulation on (18)F-FRP170 PET represents viable hypoxic tissues in glioblastoma. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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