Clinically useful dilution factors for iodine and gadolinium contrast material: an animal model of pediatric digital subtraction angiography using state-of-the-art flat-panel detectors.
Background: Iodinated and gadolinium contrast agents pose some risk for certain pediatric patients, including allergic-like reactions, contrast-induced nephropathy (CIN) and nephrogenic systemic fibrosis (NSF). Digital flat-panel detectors enhance image quality during angiography and might allow use...
| Publicado en: | Pediatric Radiology Vol. 43; no. 11; pp. 1491 - 1502 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Nov2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104106035&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104106035 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Nov2013 vid: 43 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104106035 NLM23736781 2012342702 10.1007/s00247-013-2723-0 NLM23736781 104106035 ppf: 1491 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Clinically useful dilution factors for iodine and gadolinium contrast material: an animal model of pediatric digital subtraction angiography using state-of-the-art flat-panel detectors. aug: au: Racadio, John M Kashinkunti, Soumya R Nachabe, Rami A Racadio, Judy M Johnson, Neil D Kukreja, Kamlesh U Patel, Manish N Privitera, Mary Beth Hales, Jasmine E Abruzzo, Todd A affil: Department of Radiology, Division of Pediatric Interventional Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229-3030, USA, john.racadio@cchmc.org. sug: subj: Angiography, Digital Subtraction Equipment and Supplies Elements Administration and Dosage Elements Diagnostic Use Iodine Administration and Dosage Iodine Diagnostic Use Models, Biological Radiographic Image Enhancement Angiography, Digital Subtraction Methods Animal Studies Contrast Media Contrast Media Administration and Dosage Dose-Response Relationship, Drug Elements Equipment Design Equipment Failure Iodine Rabbits Reproducibility of Results Sensitivity and Specificity ab: Background: Iodinated and gadolinium contrast agents pose some risk for certain pediatric patients, including allergic-like reactions, contrast-induced nephropathy (CIN) and nephrogenic systemic fibrosis (NSF). Digital flat-panel detectors enhance image quality during angiography and might allow use of more dilute contrast material to decrease risk of complications that might be dose-dependent, such as CIN and NSF.Objective: To assess the maximum dilution factors for iodine- and gadolinium-based contrast agents suitable for vascular imaging with fluoroscopy and digital subtraction angiography (DSA) on digital flat-panel detectors in an animal model.Materials and Methods: We performed selective catheterization of the abdominal aorta, renal artery and common carotid artery on a rabbit. In each vessel we performed fluoroscopy and DSA during contrast material injection using iodinated and gadolinium contrast material at 100%, 80%, 50%, 33% and 20% dilutions. An image quality score (0 to 3) was assigned by each of eight evaluators. Intracorrelation coefficient, paired t-test, one-way repeated analysis of variance, Spearman correlation and receiver operating characteristic curve analysis were applied to the data.Results: Overall the image quality scores correlated linearly with dilution levels. For iodinated contrast material, the optimum cut-off level for DSA when a score of at least 2 is acceptable is above 33%; it is above 50% when a score of 3 is necessary. For gadolinium contrast material, the optimum cut-off for DSA images is above 50% when a score of at least 2 is acceptable and above 80% when a score of 3 is necessary.Conclusion: Knowledge of the relationship between image quality and contrast material dilution might allow a decrease in overall contrast load while maintaining appropriate image quality when using digital flat-panel detectors. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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