Sensitivity of rabbit ventricular action potential and ca (2+) dynamics to small variations in membrane currents and ion diffusion coefficients.

Little is known about how small variations in ionic currents and Ca²¿ and Na¿ diffusion coefficients impact action potential and Ca²¿ dynamics in rabbit ventricular myocytes. We applied sensitivity analysis to quantify the sensitivity of Shannon et al. model (Biophys. J., 2004) to 5%-10% changes in...

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Bibliographic Details
Published in:BioMed Research International Vol. 2013; pp. 565431 - 565432
Main Authors: Lo, Yuan Hung, Peachey, Tom, Abramson, David, McCulloch, Andrew, Michailova, Anushka
Format: Journal Article
Published: Wiley-Blackwell 2013
Online Access:View this record in EBSCOhost