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Computational modeling of the human atrial anatomy and electrophysiology.

This review article gives a comprehensive survey of the progress made in computational modeling of the human atria during the last 10 years. Modeling the anatomy has emerged from simple "peanut"-like structures to very detailed models including atrial wall and fiber direction. Electrophysiological m...

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Publicado en:Medical & Biological Engineering & Computing Vol. 50; no. 8; pp. 773 - 800
Autores principales: Dössel O, Krueger MW, Weber FM, Wilhelms M, Seemann G, Dössel, Olaf, Krueger, Martin W, Weber, Frank M, Wilhelms, Mathias, Seemann, Gunnar
Formato: research review Journal Article
Publicado: Springer Nature Aug2012
Acceso en línea:Ver este registro en EBSCOhost
Sumario:This review article gives a comprehensive survey of the progress made in computational modeling of the human atria during the last 10 years. Modeling the anatomy has emerged from simple "peanut"-like structures to very detailed models including atrial wall and fiber direction. Electrophysiological models started with just two cellular models in 1998. Today, five models exist considering e.g. details of intracellular compartments and atrial heterogeneity. On the pathological side, modeling atrial remodeling and fibrotic tissue are the other important aspects. The bridge to data that are measured in the catheter laboratory and on the body surface (ECG) is under construction. Every measurement can be used either for model personalization or for validation. Potential clinical applications are briefly outlined and future research perspectives are suggested.