Fast-specific tomography imaging via Cerenkov emission.

Purpose: Development of more tumor-specific radiopharmaceuticals is not enough; to understand the disease, we must study data modeling. Although fluoro-18-deoxyglucose positron emission tomography can map a multi-peak distribution of trace radioisotopes, optical tomography should also be able to red...

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Detalles Bibliográficos
Publicado en:Molecular Imaging & Biology Vol. 14; no. 3; pp. 286 - 293
Autores principales: Zhong J, Qin C, Yang X, Chen Z, Tian J, Zhong, Jianghong, Qin, Chenghu, Yang, Xin, Chen, Zhe, Yang, Xiang, Tian, Jie
Formato: research Journal Article
Publicado: Springer Nature Jun2012
Acceso en línea:Ver este registro en EBSCOhost
Descripción
Sumario:Purpose: Development of more tumor-specific radiopharmaceuticals is not enough; to understand the disease, we must study data modeling. Although fluoro-18-deoxyglucose positron emission tomography can map a multi-peak distribution of trace radioisotopes, optical tomography should also be able to redirect the distribution.Procedures: Multi-view image acquisition of small animals injected with 2-deoxy-2-[(18)F]fluoro-D: -glucose began with X-ray computed tomography scanning and Cerenkov luminescence imaging. After fusion processing, utilization of the geometric row scaling and L (1/2) regularization operator effectively generates in vivo Cerenkov luminescence tomography images with the SP(3) forward model.Results: The identification is confirmed by the comparison between tumor-specific tomography from Cerenkov emission and the radioactivity measured in vitro.Conclusion: The proposed technique can quickly localize the mobility of radionuclides and uptake by organs, which provides an imaging methodology in oncology.