Clear cell sarcoma expressing a novel chimerical transcript EWSR1 exon 7/ATF1 exon 6.

Clear cell sarcoma harbours recurrent translocation, resulting in EWSR1/ATF1 or less commonly EWSR1/CREB1 fusion. To date, six types of EWSR1/ATF1 fusion have been reported, of which three are in-frame and encode functional proteins. We present a reverse transcription - polymerase chain reaction ana...

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Detalles Bibliográficos
Publicado en:	Virchows Archiv: European Journal of Pathology Vol. 461; no. 3; pp. 339 - 344
Autores principales:	Gineikiene E, Seinin D, Brasiuniene B, Brazaitis A, Griskevicius L, Jakubauskas A, Gineikiene, Egle, Seinin, Dmitrij, Brasiuniene, Birute, Brazaitis, Andrius, Griskevicius, Laimonas, Jakubauskas, Arturas
Formato:	case study Journal Article
Publicado:	Springer Nature Sep2012
Acceso en línea:	Ver este registro en EBSCOhost

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Sumario:	Clear cell sarcoma harbours recurrent translocation, resulting in EWSR1/ATF1 or less commonly EWSR1/CREB1 fusion. To date, six types of EWSR1/ATF1 fusion have been reported, of which three are in-frame and encode functional proteins. We present a reverse transcription - polymerase chain reaction analysis of a tumour near the hallux of the right foot. The sequencing of obtained fragments revealed the presence of a novel chimerical transcript-the in-frame fusion between EWSR1 exon 7 and ATF1 exon 6 that represents the fourth in-frame type of EWSR1/ATF1 fusion identified in clear cell sarcomas.