Clear cell sarcoma expressing a novel chimerical transcript EWSR1 exon 7/ATF1 exon 6.
Clear cell sarcoma harbours recurrent translocation, resulting in EWSR1/ATF1 or less commonly EWSR1/CREB1 fusion. To date, six types of EWSR1/ATF1 fusion have been reported, of which three are in-frame and encode functional proteins. We present a reverse transcription - polymerase chain reaction ana...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 461; no. 3; pp. 339 - 344 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Springer Nature
Sep2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104444715&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104444715 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Sep2012 vid: 461 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104444715 104444715 NLM22886438 2011754008 10.1007/s00428-012-1295-y NLM22886438 104444715 ppf: 339 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Clear cell sarcoma expressing a novel chimerical transcript EWSR1 exon 7/ATF1 exon 6. aug: au: Gineikiene E Seinin D Brasiuniene B Brazaitis A Griskevicius L Jakubauskas A Gineikiene, Egle Seinin, Dmitrij Brasiuniene, Birute Brazaitis, Andrius Griskevicius, Laimonas Jakubauskas, Arturas affil: Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Klinikos, Santariskiu 2, Vilnius 08661, Lithuania sug: subj: Proteins Sarcoma Soft Tissue Neoplasms Adult Antineoplastic Agents, Combined Bone Neoplasms Genes Fatal Outcome Toes Neoplasm Metastasis Male Reverse Transcriptase Polymerase Chain Reaction Soft Tissue Neoplasms Drug Therapy Soft Tissue Neoplasms Pathology Chromosome Disorders Adult: 19-44 years Male ab: Clear cell sarcoma harbours recurrent translocation, resulting in EWSR1/ATF1 or less commonly EWSR1/CREB1 fusion. To date, six types of EWSR1/ATF1 fusion have been reported, of which three are in-frame and encode functional proteins. We present a reverse transcription - polymerase chain reaction analysis of a tumour near the hallux of the right foot. The sequencing of obtained fragments revealed the presence of a novel chimerical transcript-the in-frame fusion between EWSR1 exon 7 and ATF1 exon 6 that represents the fourth in-frame type of EWSR1/ATF1 fusion identified in clear cell sarcomas. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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