A grid overlay framework for analysis of medical images and its application to the measurement of stroke lesions.
Objectives: To create and evaluate an interactive software tool for measuring imaging data in situations where hand-drawn region-of-interest measurements are unfeasible, for example, when the structure of interest is patchy with ill-defined boundaries.Methods: An interactive grid overlay software to...
| Published in: | European Radiology Vol. 22; no. 3; pp. 625 - 633 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Mar2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104511929&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104511929 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2012 vid: 22 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104511929 NLM21947484 2011449165 10.1007/s00330-011-2284-2 NLM21947484 104511929 ppf: 625 ppct: 8 formats: fmt: @attributes: type: P tig: atl: A grid overlay framework for analysis of medical images and its application to the measurement of stroke lesions. aug: au: Armitage PA Rivers CS Karaszewski B Thomas RG Lymer GK Morris Z Wardlaw JM Armitage, Paul A Rivers, C S Karaszewski, B Thomas, R G R Lymer, G K Morris, Z Wardlaw, J M affil: Division of Clinical Neurosciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland, UK sug: subj: Image Interpretation, Computer Assisted Methods Magnetic Resonance Imaging Software Stroke Pathology Aged Aged, 80 and Over Contrast Media Diagnostic Use Female Human Male Sorbitol Diagnostic Use Organometallic Compounds Diagnostic Use Prospective Studies Reproducibility of Results User-Computer Interface Aged: 65+ years Aged, 80 & over Female Male ab: Objectives: To create and evaluate an interactive software tool for measuring imaging data in situations where hand-drawn region-of-interest measurements are unfeasible, for example, when the structure of interest is patchy with ill-defined boundaries.Methods: An interactive grid overlay software tool was implemented that enabled coding of voxels dependent on their imaging appearance with a series of user-defined classes. The Grid Analysis Tool (GAT) was designed to automatically extract quantitative imaging data, grouping the results by tissue class. Inter- and intra-observer reproducibility was evaluated by six observers of various backgrounds in a study of acute stroke patients.Results: The software tool enabled a more detailed classification of the stroke lesion than would be possible with a region-of-interest approach. However, inter-observer coefficients of variation (CVs) were relatively high, reaching 70% in "possibly abnormal" tissue and around 15-20% in normal appearing tissues, while intra-observer CVs were no more than 13% in "possibly abnormal" tissue and generally less than 1% in normal-appearing tissues.Conclusions: The grid-overlay method overcomes some of the limitations of conventional Region Of Interest (ROI) approaches, providing a viable alternative for segmenting patchy lesions with ill-defined boundaries, but care is required to ensure acceptable reproducibility if the method is applied by multiple observers.Key Points: Computer software developed to overcome limitations of conventional regions of interest measurements • This software is suitable for patchy lesions with ill-defined borders • Allows a more detailed assessment of imaging data. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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