Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping.

Purpose: To develop a limited sampling strategy (LSS) to predict area under the concentration-time curve (AUC) ratios of omeprazole (AUC) to its metabolites 5-hydroxyomeprazole (AUC) and omeprazole sulfone (AUC) as phenotyping parameters for cytochrome P450 (CYP) 2C19 and 3A. Methods: Data were obta...

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Bibliographic Details

Published in:	European Journal of Clinical Pharmacology Vol. 68; no. 4; pp. 407 - 414
Main Authors:	Lawson, Eileen, Wu, Jerry, Baldwin, R., Ingelman-Sundberg, Magnus, Rosenborg, Staffan, Yim, Dong-Seok, Yin, Ophelia, Capparelli, Edmund, Ma, Joseph
Format:	research tables/charts Journal Article
Published:	Springer Nature Apr2012
Online Access:	View this record in EBSCOhost