Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping.
Purpose: To develop a limited sampling strategy (LSS) to predict area under the concentration-time curve (AUC) ratios of omeprazole (AUC) to its metabolites 5-hydroxyomeprazole (AUC) and omeprazole sulfone (AUC) as phenotyping parameters for cytochrome P450 (CYP) 2C19 and 3A. Methods: Data were obta...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 68; no. 4; pp. 407 - 414 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2012
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| Acceso en línea: | Ver este registro en EBSCOhost |