| Summary: | Objective: If there are two previous miscarriages, the risk of miscarriage in the next pregnancy is 26% . Presence of three previous miscarriages increases this risk upto 32%. We have aimed to find whether or not there is a difference between the women with habitual abortion (three or more fetal losses) and women with two fetal losses in relation to thrombophilic factors. Material and Methods: A total of 108 women aged between 17-40 years who admitted to the infertility department were included in the study. None of the patients were pregnant. Patients were divided into two groups as women with three or more subsequent pregnancy losses, which was defined as habitual abortus, and women with two abortuses, and then both groups underwent thrombophilia workup. There were 66 patients in the first group and 42 patients in the second group. Results: We did not find any significant difference between the groups in relation to folic acid, vitamin B12, homocystein, antithrombin III, protein S levels or presence of activated protein C resistance, prothrombin G mutation, and factor V mutation. There were no pathological findings on hysterosalpingography and pelvic ultrasonography of the patients. Conclusion: As a result, we believe that investigation for thrombophilia should be performed in women with two recurrent miscarriages (without regarding the early or late abortions), before the occurence of three fetal losses. One may expect that this approach will protect patients from losing their next pregnancies by preventing late diagnosis and the treatment of thrombophilia. However, our opinion should be supported by prospective cohort studies with a greater sample size.
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