Massive metformin overdose in two subjects with suividal behavior: brief communication.
Lactic acidosis is a well-recognized side effect of metformin, especially in patients with renal failure. Only a few cases of deliberate self-poisoning with metformin have been described in the literature. The mechanism of metformin-associated lactic acidosis is complex. In the absence of acute over...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 32; no. 2; pp. 559 - 563 |
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| Autores principales: | , , , , |
| Formato: | case study tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Apr2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | Lactic acidosis is a well-recognized side effect of metformin, especially in patients with renal failure. Only a few cases of deliberate self-poisoning with metformin have been described in the literature. The mechanism of metformin-associated lactic acidosis is complex. In the absence of acute overdose, metformin-associated lactic acidosis rarely develops in patients without comorbidities such as renal or hepatic insufficiency or acute infection. We report two patients who had a large dose of metformin in an attempt to harm themselves and presented with lactic acidosis. In our experience, metformin intoxication may lead a high anion gap metabolic acidosis after a suicide attempt. Sodium bicarbonate infusion is able to correct the acid-base metabolism sufficiently in subjects with normal renal functions. |
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