Massive metformin overdose in two subjects with suividal behavior: brief communication.
Lactic acidosis is a well-recognized side effect of metformin, especially in patients with renal failure. Only a few cases of deliberate self-poisoning with metformin have been described in the literature. The mechanism of metformin-associated lactic acidosis is complex. In the absence of acute over...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 32; no. 2; pp. 559 - 563 |
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| Autores principales: | , , , , |
| Formato: | case study tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Apr2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104546022&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104546022 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Apr2012 vid: 32 iid: 2 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104546022 104546022 2011506231 10.5336/medsci.2010-19297 104546022 ppf: 559 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Massive metformin overdose in two subjects with suividal behavior: brief communication. aug: au: Arikan, Senay Tuzcu, Alpaslan Bahceci, Mithat Kaplan, Mehmet Ali Gokalp, Deniz affil: Department of Endocrinology, Dicle University Faculty of Medicine, Diyarbak?r sug: subj: Acidosis, Lactic Diagnosis Bicarbonates Metformin Poisoning Overdose Adult Female Male Suicide Adult: 19-44 years Female Male ab: Lactic acidosis is a well-recognized side effect of metformin, especially in patients with renal failure. Only a few cases of deliberate self-poisoning with metformin have been described in the literature. The mechanism of metformin-associated lactic acidosis is complex. In the absence of acute overdose, metformin-associated lactic acidosis rarely develops in patients without comorbidities such as renal or hepatic insufficiency or acute infection. We report two patients who had a large dose of metformin in an attempt to harm themselves and presented with lactic acidosis. In our experience, metformin intoxication may lead a high anion gap metabolic acidosis after a suicide attempt. Sodium bicarbonate infusion is able to correct the acid-base metabolism sufficiently in subjects with normal renal functions. pubtype: Academic Journal doctype: case study tables/charts Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
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