Population pharmacokinetics of metformin in obese and non-obese patients with type 2 diabetes mellitus.
Purpose: The objective of this study was to develop a population pharmacokinetic model and investigate the effect of several demographic covariates on metformin pharmacokinetics in patients with type 2 diabetes mellitus, over a wide range of weights. Methods: A total of 105 patients received differe...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 68; no. 6; pp. 961 - 969 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104567762&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104567762 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Jun2012 vid: 68 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104567762 75178538 10.1007/s00228-011-1207-0 NLM22274405 104567762 ppf: 961 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Population pharmacokinetics of metformin in obese and non-obese patients with type 2 diabetes mellitus. aug: au: Bardin, Christophe Nobecourt, Estelle Larger, Etienne Chast, François Treluyer, Jean-Marc Urien, Saik affil: Pharmacy-Pharmacology-Toxicology Department, Hôtel-Dieu, AP-HP, 1, Place du Parvis Notre-Dame 75181 Paris Cédex 04 France sug: subj: Diabetes Mellitus, Type 2 Drug Therapy Metformin Administration and Dosage Metformin Pharmacokinetics Human Models, Statistical Obesity Body Weight Chromatography, High Pressure Liquid Metformin Blood Fat Free Mass Metabolic Clearance Rate Biological Availability Creatinine Blood Age Factors Kidney Male Female Biological Assay Data Analysis Software Descriptive Statistics Adult Middle Age Aged Aged, 80 and Over Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Purpose: The objective of this study was to develop a population pharmacokinetic model and investigate the effect of several demographic covariates on metformin pharmacokinetics in patients with type 2 diabetes mellitus, over a wide range of weights. Methods: A total of 105 patients received different metformin regimens, and pharmacokinetic sampling included a minimum of two concentrations per patient. Plasma determination of metformin was assayed by high performance liquid chromatography. Population pharmacokinetics was modelled using a nonlinear mixed effects model program (Monolix version 3.1 s). Results: An open one-compartment model adequately described metformin data. Lean body weight was a better size descriptor than actual body weight or ideal body weight for clearance (CL/F) and volume (V/F) parameters. CL/F was negatively related to age and serum creatinine (SCr). The estimation of specific coefficients for these effects gave better results than the use of renal function descriptors (Cockroft or MDRD). A dose effect in the relative bioavailability was demonstrated. Conclusion: The pharmacokinetics of metformin was influenced by lean body weight on an allometric basis and was related to markers of renal function, age, and serum creatinine in this population of 105 patients. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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