Effects of Thymus sipyleus and Taurine on Hepatic MDA, GSH, AOPP Levels and SOD Activity in Ehrlich Acide Solid Tumor Model Generated Mice.
Objective: In this study, effects of taurine (200 mg/kg/day) and Thymus sipyleus Boiss. subspecies sipyleus variety sipyleus (thyme) methanol extract (1.5 g/kg/day) administration on advanced oxidation protein products (AOPPs), malondialdehyde (MDA), glutathione (GSH) levels and superoxide dismutase...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 31; no. 5; pp. 1153 - 1160 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Oct2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104607248&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104607248 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Oct2011 vid: 31 iid: 5 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104607248 104607248 2011385449 10.5336/medsci.2010-21062 104607248 ppf: 1153 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Effects of Thymus sipyleus and Taurine on Hepatic MDA, GSH, AOPP Levels and SOD Activity in Ehrlich Acide Solid Tumor Model Generated Mice. aug: au: Turna, Gamze Kiliç, Nedret Yildirim, Zuhal Sari, Salih sug: subj: Amino Acids Liver Neoplasms Drug Therapy Malondialdehyde Superoxide Dismutase Thymus Gland Animal Studies Mice Models, Biological Treatment Outcomes ab: Objective: In this study, effects of taurine (200 mg/kg/day) and Thymus sipyleus Boiss. subspecies sipyleus variety sipyleus (thyme) methanol extract (1.5 g/kg/day) administration on advanced oxidation protein products (AOPPs), malondialdehyde (MDA), glutathione (GSH) levels and superoxide dismutase (SOD) activity in liver tissue of Swiss albino mice were investigated. Material and Methods: Test subjects were divided into six groups as healthy control, tumor control, thyme protection, thyme treatment, taurine protection and taurine treatment (n= 6). Substance was given to protection groups for 17 days beginning from the first day following tumor injection. Substance was given to treatment groups for seven days beginning from eleventh day following tumor injection. Results: When tumor control and taurine treatment groups were compared, AOPP level of taurine treatment group was found to decrease significantly (p< 0.05). When tumor control and healthy control groups were compared, AOPP level of tumor control group was seen to increase, however this increase was not found to be significant (p> 0.05). When tumor control and taurine protection groups were compared, MDA level of taurine protection group was found to decrease significantly (p< 0.05). When tumor control and taurine protection groups were compared , GSH level of taurine protection group was found to increase, however this increase was not found significant (p> 0.05). When tumor control and thyme treatment groups were compared, SOD activity of thyme treatment group was found to increase significantly (p< 0.05). Conclusion: In conclusion, while taurine administration decreased MDA and AOPP levels that increased with oxidative stress, it did not significantly affect GSH levels and SOD activity. While thymus sipyleus methanol extract increased SOD activity, it did not affect MDA, AOPP and GSH levels significantly. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
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