Effective reduction of the interleukin-1β transcript in osteoarthritis-prone guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences gene expression of mediators implicated in disease pathogenesis.
Objective: To ascertain a viral vector-based short hairpin RNA (shRNA) capable of reducing the interleukin-1β (IL-1β) transcript in osteoarthritis (OA)-prone chondrocytes and detect corresponding changes in the expression patterns of several critical disease mediators.Methods: Cultured chondrocytes...
| Publicado en: | Osteoarthritis & Cartilage Vol. 19; no. 12; pp. 1449 - 1458 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Dec2011
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| Acceso en línea: | Ver este registro en EBSCOhost |