Comparing the effects of stimulation and propofol infusion rate on implicit and explicit memory formation.
Doubt remains about the conditions under which learning persists despite anaesthesia. This study investigated the relative importance of dose of anaesthetic and stimulation for learning during propofol infusion before surgery. Thirty-six patients were randomly assigned to three groups. Group 1 recei...
| Publicado en: | BJA: The British Journal of Anaesthesia Vol. 86; no. 2; pp. 189 - 196 |
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| Autores principales: | , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
Elsevier B.V.
Feb2001
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104725988&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104725988 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00070912 1FZ jtl: BJA: The British Journal of Anaesthesia issn: 00070912 maglogo: N pubinfo: dt: Feb2001 vid: 86 iid: 2 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 104725988 104725988 NLM11573658 2011083736 NLM11573658 104725988 ppf: 189 ppct: 7 formats: tig: atl: Comparing the effects of stimulation and propofol infusion rate on implicit and explicit memory formation. aug: au: Andrade, J Englert, L Harper, C Edwards, N D affil: Department of Psychology, University of Sheffield, UK. sug: subj: Anesthetics, Intravenous Pharmacodynamics Memory Drug Effects Propofol Pharmacodynamics Anesthetics, Intravenous Administration and Dosage Anesthetics, Intravenous Blood Drug Administration Schedule Electroencephalography Female Human Infusions, Intravenous Intubation, Intratracheal Learning Drug Effects Pilot Studies Postoperative Period Propofol Administration and Dosage Propofol Blood Psychological Tests Clinical Trials Female ab: Doubt remains about the conditions under which learning persists despite anaesthesia. This study investigated the relative importance of dose of anaesthetic and stimulation for learning during propofol infusion before surgery. Thirty-six patients were randomly assigned to three groups. Group 1 received two word lists (category examples and nonsense words) during infusion of propofol to a target concentration of 2 microg ml(-1). Groups 2 and 3 received the word lists during infusion of propofol 5 microg ml(-1). Group 2 received nonsense words before tracheal intubation and category examples during intubation; Group 3 heard category examples before and nonsense words during intubation. Bispectral index was recorded as a measure of depth of sedation/anaesthesia. We assessed explicit memory on recovery using a structured interview and a recognition test. We assessed implicit memory using a category generation test and a preference rating task. To establish baseline, a control group of 12 patients completed the category generation test without receiving the category examples during anaesthesia. Overall, there was no evidence for learning during propofol infusion, though the category generation task showed a trend towards more implicit memory for words presented during intubation than during anaesthesia. We conclude that learning does not occur during anaesthesia without surgery. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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