| Sumario: | Acute non-lymphocytic leukemia is characterized by excessive accumulation of immature non lymphocytic bone marrow precursor cells in the marrow itself, and in peripheral blood. Here, a 23 year-old female patient with acute nonlymphocytic leukemia with inversion 16 and trisomy 22 cytogenetic findings is presented. As known, inversion 16 is generally related to acute myeloid leukemia M4 subtype. Trisomy 22 which represents poor prognosis is generally reported with inversion 16 in acute myeloid leukemia. Our case was treated with idarubicin and cytosine arabinoside at her initial diagnosis phase two years ago. In the relapse phase, trisomy 22 and inversion 16 was found sixteen months later. After the idarubicin and cytosine arabinoside treatment, blastic cell ratio was found to be 9.8% and myelosuppression occurred. This finding represents the necessity of detailed cytogenetic and molecular cytogenetic analyses in leukemia cases in initial diagnosis and treatment phases for predicting the prognosis.
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