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Co-occurrence of inversion 16 and trisomy 22 cytogenetic abnormalities in a relapse phase acute non-lymphocytic leukemia case.

Acute non-lymphocytic leukemia is characterized by excessive accumulation of immature non lymphocytic bone marrow precursor cells in the marrow itself, and in peripheral blood. Here, a 23 year-old female patient with acute nonlymphocytic leukemia with inversion 16 and trisomy 22 cytogenetic findings...

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Published in:Turkiye Klinikleri Journal of Medical Sciences Vol. 30; no. 6; pp. 2037 - 2041
Main Authors: Kozan, Salih, Ates, Omer, Güran, Sefik, Bahçe, Muhterem, Beyan, Cengiz
Format: case study pictorial Journal Article
Published: Turkiye Klinikleri Dec2010
Online Access:View this record in EBSCOhost
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      dt: Dec2010
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      pub: Turkiye Klinikleri
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        atl: Co-occurrence of inversion 16 and trisomy 22 cytogenetic abnormalities in a relapse phase acute non-lymphocytic leukemia case.
      aug:
        au:
          Kozan, Salih
          Ates, Omer
          Güran, Sefik
          Bahçe, Muhterem
          Beyan, Cengiz
      sug:
        subj:
          Aneuploidy
          Leukemia, Myeloid Familial and Genetic
          Adult
          Female
          Adult: 19-44 years
          Female
      ab: Acute non-lymphocytic leukemia is characterized by excessive accumulation of immature non lymphocytic bone marrow precursor cells in the marrow itself, and in peripheral blood. Here, a 23 year-old female patient with acute nonlymphocytic leukemia with inversion 16 and trisomy 22 cytogenetic findings is presented. As known, inversion 16 is generally related to acute myeloid leukemia M4 subtype. Trisomy 22 which represents poor prognosis is generally reported with inversion 16 in acute myeloid leukemia. Our case was treated with idarubicin and cytosine arabinoside at her initial diagnosis phase two years ago. In the relapse phase, trisomy 22 and inversion 16 was found sixteen months later. After the idarubicin and cytosine arabinoside treatment, blastic cell ratio was found to be 9.8% and myelosuppression occurred. This finding represents the necessity of detailed cytogenetic and molecular cytogenetic analyses in leukemia cases in initial diagnosis and treatment phases for predicting the prognosis.
      pubtype: Academic Journal
      doctype:
        case study
        pictorial
        Journal Article
      ougenre: Article
    language: Turkish
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