Combined correction of recovery effect and motion blur for SUV quantification of solitary pulmonary nodules in FDG PET/CT.
Objective: We evaluate a fully data-driven method for the combined recovery and motion blur correction of small solitary pulmonary nodules (SPNs) in F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT).Methods: The SPN was segmented in the low-dose CT using a var...
| Published in: | European Radiology Vol. 20; no. 8; pp. 1868 - 1878 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Aug2010
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104912172&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104912172 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2010 vid: 20 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104912172 51989449 NLM20306084 2010709995 10.1007/s00330-010-1747-1 NLM20306084 104912172 ppf: 1868 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Combined correction of recovery effect and motion blur for SUV quantification of solitary pulmonary nodules in FDG PET/CT. aug: au: Apostolova I Wiemker R Paulus T Kabus S Dreilich T van den Hoff J Plotkin M Mester J Brenner W Buchert R Klutmann S Apostolova, Ivayla Wiemker, Rafael Paulus, Timo Kabus, Sven Dreilich, Thomas van den Hoff, Jörg Plotkin, Michail Mester, Janos Brenner, Winfried affil: Department of Nuclear Medicine, University Medicine Charité Berlin, Berlin, Germany sug: subj: Algorithms Artifacts Fludeoxyglucose F 18 Diagnostic Use Image Enhancement Methods Image Interpretation, Computer Assisted Methods Lung Neoplasms Diagnosis Tomography, X-Ray Computed Methods Aged Female Human Male Motion Phantoms, Imaging Radiopharmaceuticals Diagnostic Use Reproducibility of Results Sensitivity and Specificity Aged: 65+ years Female Male ab: Objective: We evaluate a fully data-driven method for the combined recovery and motion blur correction of small solitary pulmonary nodules (SPNs) in F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT).Methods: The SPN was segmented in the low-dose CT using a variable Hounsfield threshold and morphological constraints. The combined effect of limited spatial resolution and motion blur in the SPN's PET image was then modelled by an effective Gaussian point-spread function (psf). Both isotropic and non-isotropic psfs were used. To validate the method, PET/CT measurements of the NEMA/IEC spheres phantom were performed. The method was applied to 50 unselected SPNs <or=30 mm from routine patient care.Results: Recovery of standardised uptake value (SUV) in the phantom image was significantly improved by combined recovery and motion blur correction compared with recovery-only correction, particularly with the non-isotropic model (residual average error 10%). In the patient images, automated segmentation and fit of the effective psf worked properly in all cases. Volume-equivalent diameter ranged from 4.9 to 27.8 mm. Uncorrected maximum SUV ranged from 0.9 to 13.3. Compared with recovery-only correction, combined correction with the non-isotropic model resulted in a 'relevant' (>or=30%) SUV increase in 47 SPNs (94%).Conclusions: Correction of both recovery and motion blur is mandatory for accurate SUV quantification of SPNs. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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