Could CD4 capture by CD8+ T cells play a role in HIV spreading?
CD8(+) T cells have been shown to capture plasma membrane fragments from target cells expressing their cognate antigen, a process termed 'trogocytosis'. Here, we report that human CD4, the Human Immunodeficiency Virus (HIV) receptor, can be found among the proteins transferred by trogocytosis. CD4 i...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 907371 - 907372 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | CD8(+) T cells have been shown to capture plasma membrane fragments from target cells expressing their cognate antigen, a process termed 'trogocytosis'. Here, we report that human CD4, the Human Immunodeficiency Virus (HIV) receptor, can be found among the proteins transferred by trogocytosis. CD4 is expressed in a correct orientation after its capture by CD8(+) T cells as shown by its detection using conformational antibodies and its ability to allow HIV binding on recipient CD8(+) T cells. Although we could not find direct evidence for infection of CD8(+) T cells having captured CD4 by HIV, CD4 was virologically functional on these cells as it conferred on them the ability to undergo syncytia formation induced by HIV-infected MOLT-4 cells. Our results show that acquisition of CD4 by CD8(+) T cells via trogocytosis could play a previously unappreciated role for CD8(+) T cells in HIV spreading possibly without leading to their infection. |
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