Could CD4 capture by CD8+ T cells play a role in HIV spreading?
CD8(+) T cells have been shown to capture plasma membrane fragments from target cells expressing their cognate antigen, a process termed 'trogocytosis'. Here, we report that human CD4, the Human Immunodeficiency Virus (HIV) receptor, can be found among the proteins transferred by trogocytosis. CD4 i...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 907371 - 907372 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2010
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105082076&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105082076 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2010 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105082076 105082076 2010748449 NLM20368790 PMC2846356 105082076 ppf: 907371 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Could CD4 capture by CD8+ T cells play a role in HIV spreading? aug: au: Aucher A Puigdomènech I Joly E Clotet B Hudrisier D Blanco J affil: Institut de Pharmacologie et de Biologie Structurale (CNRS, IPBS), 205 route de Narbonne, 31077 Toulouse, France. sug: subj: Antigens, CD4 Immunology HIV Infections HIV Infections Immunology Human Immunodeficiency Virus Physiology T Lymphocytes Immunology Animal Studies Cells Flow Cytometry HLA Antigens Immunology Human Human Immunodeficiency Virus Immunology Immune System Mice T Lymphocytes Viruses Viruses Metabolism ab: CD8(+) T cells have been shown to capture plasma membrane fragments from target cells expressing their cognate antigen, a process termed 'trogocytosis'. Here, we report that human CD4, the Human Immunodeficiency Virus (HIV) receptor, can be found among the proteins transferred by trogocytosis. CD4 is expressed in a correct orientation after its capture by CD8(+) T cells as shown by its detection using conformational antibodies and its ability to allow HIV binding on recipient CD8(+) T cells. Although we could not find direct evidence for infection of CD8(+) T cells having captured CD4 by HIV, CD4 was virologically functional on these cells as it conferred on them the ability to undergo syncytia formation induced by HIV-infected MOLT-4 cells. Our results show that acquisition of CD4 by CD8(+) T cells via trogocytosis could play a previously unappreciated role for CD8(+) T cells in HIV spreading possibly without leading to their infection. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|