Effects of antioxidants on postprandial oxidative stress and endothelial dysfunction in subjects with impaired glucose tolerance and type 2 diabetes.
AIM: To compare changes in the oxidation-reduction balance and endothelial function before and after meal in patients with type 2 diabetes or impaired glucose tolerance and determine the effects of standard antioxidant supplementation. METHODS: Forty diabetics and 40 subjects with impaired glucose t...
| Publicado en: | European Journal of Nutrition Vol. 49; no. 7; pp. 409 - 417 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105106548&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105106548 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Oct2010 vid: 49 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105106548 2010802156 10.1007/s00394-010-0099-6 NLM20213326 105106548 ppf: 409 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Effects of antioxidants on postprandial oxidative stress and endothelial dysfunction in subjects with impaired glucose tolerance and type 2 diabetes. aug: au: Neri S Calvagno S Mauceri B Misseri M Tsami A Vecchio C Mastrosimone G Di Pino A Maiorca D Judica A Romano G Rizzotto A Signorelli SS affil: Department of Internal Medicine and Systemic Disease, University of Catania, Catania, Italy; sergio.neri4@tin.it sug: subj: Antioxidants Metabolism Cells Metabolism Diabetes Mellitus, Type 2 Glucose Intolerance Oxidative Stress Postprandial Period Adult Analysis of Variance Female Funding Source Human Italy Kruskal-Wallis Test Male Middle Age Post Hoc Analysis T-Tests Wilcoxon Rank Sum Test Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: AIM: To compare changes in the oxidation-reduction balance and endothelial function before and after meal in patients with type 2 diabetes or impaired glucose tolerance and determine the effects of standard antioxidant supplementation. METHODS: Forty diabetics and 40 subjects with impaired glucose tolerance were compared with a control group. We assessed before and after a test meal (homogenized milkshake containing 80 g of saturated fat, amounting to 1,480 kcal), some reactive oxygen species, inflammation markers and flow-mediated vascular dilatation. These parameters were then reassessed after standard antioxidant treatment. RESULTS: After the meal, diabetics, subjects with impaired glucose tolerance and controls had higher levels of oxidant compounds compared to fasting levels. In subjects with diabetes and impaired glucose tolerance (IGT), Vascular Adhesion Molecule-1 and CRP were higher after the meal -- diabetic subjects exhibited lower fasting flow-mediated dilatation, which deteriorated significantly after the meal. Antioxidant administration significantly improved the parameters investigated in all subjects. CONCLUSIONS: In diabetic subjects, altered glycaemia and lipaemia are closely correlated with markers of systemic oxidative stress. Our results show that the abnormal changes in oxidative-reductive balance parameters are paralleled by similar changes in markers of endothelial dysfunction and inflammation at 4 h after ingestion of a fatty meal. Supplementation with a pool of antioxidants can reduce oxidative stress and inflammation in healthy subjects and, more importantly, in IGT patients. This previous aspect suggests that the timing of antioxidant supplementation has an important role in endothelium protection in healthy and pre-diabetic subjects, and along with prompt antioxidant treatment before irreversible endothelial damage has occurred, may have an important protective role in subjects with IGT -- patients who require administration of adequate dietary antioxidants. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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