| Sumario: | Racial and ethnic populations, such as Mexican Americans (MA), experience poor access to care, limited English proficiency (LEP) and low literacy issues which influence timely receipt of quality health care and increased societal costs of cancer care. Greater research focus must occur to implement culturally sensitive interventions to help meet these groups' needs and rights for care and address health care disparities that negatively influence overall community health. Receipt of informed consent provides the ethical and legal foundation for participant involvement in research to identify culturally sensitive interventions. However, receipt and maintenance of such consent presents challenges to research teams when the participants possess LEP, low literacy levels, and hold cultural values influencing research participation. The research team examined the cancer caregiving experience among MA females and engaged in various strategies to respond to these challenges. This article describes those challenges and strategies to provide informed consent to meet both legal and ethical standards for research with a vulnerable population group. Findings may guide other researchers who value an informed consent process based on honesty, trust, and respect for ethnic group representatives that inform needed research with ethnically diverse communities.
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