The pharmacokinetics of codeine and its metabolites in Blacks with sickle cell disease.
PURPOSE: We conducted a prospective, open-label study in 54 adult subjects with sickle cell disease to determine the relationship between morphine concentrations, cytochrome P450 (CYP) 2D6 genotype, and clinical outcomes. METHODS: A blood sample was obtained for genotyping and serial blood samples w...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 65; no. 7; pp. 651 - 659 |
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| Autores principales: | , , , , , , , , |
| Formato: | clinical trial equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2009
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| Acceso en línea: | Ver este registro en EBSCOhost |