The pharmacokinetics of codeine and its metabolites in Blacks with sickle cell disease.

PURPOSE: We conducted a prospective, open-label study in 54 adult subjects with sickle cell disease to determine the relationship between morphine concentrations, cytochrome P450 (CYP) 2D6 genotype, and clinical outcomes. METHODS: A blood sample was obtained for genotyping and serial blood samples w...

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Bibliographic Details

Published in:	European Journal of Clinical Pharmacology Vol. 65; no. 7; pp. 651 - 659
Main Authors:	Shord SS, Cavallari LH, Gao W, Jeong H, Deyo K, Patel SR, Camp JR, Labott SM, Molokie RE
Format:	clinical trial equations & formulas research tables/charts Journal Article
Published:	Springer Nature Jul2009
Online Access:	View this record in EBSCOhost