Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.

BACKGROUND: Vestibular schwannomas (VS) frequently express high levels of activated AKT. Small-molecule inhibitors of AKT signalling may have therapeutic potential in suppressing the growth of benign VS and malignant schwannomas. METHOD: Primary VS and Schwann cells, human malignant schwannoma HMS-9...

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Bibliographic Details

Published in:	European Journal of Cancer Vol. 45; no. 9; pp. 1709 - 1721
Main Authors:	Lee TX, Packer MD, Huang J, Akhmametyeva EM, Kulp SK, Chen C, Giovannini M, Jacob A, Welling DB, Chang L
Format:	pictorial research tables/charts Journal Article
Published:	Pergamon Press - An Imprint of Elsevier Science Jun2009
Online Access:	View this record in EBSCOhost