Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels.
BACKGROUND: Studies have suggested that vitamin D may be important for both insulin sensitivity and insulin secretion, and that supplementation with vitamin D may subsequently prevent development of type 2 diabetes. AIM OF THE STUDY: The objective of the current study was to test the hypothesis that...
| Publicado en: | European Journal of Nutrition Vol. 48; no. 6; pp. 349 - 355 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105434325&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105434325 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Sep2009 vid: 48 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105434325 2010412528 10.1007/s00394-009-0020-3 NLM19370371 105434325 ppf: 349 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels. aug: au: Jorde R Figenschau Y affil: Institute of Clinical Medicine, University of Tromso, Tromso, Norway sug: subj: Calcitriol Blood Cholecalciferol Administration and Dosage Diabetes Mellitus, Type 2 Glycemic Control Adult Aged Analysis of Covariance Body Weights and Measures Data Analysis Software Descriptive Statistics Diabetic Patients Dietary Supplementation Female Funding Source Hematologic Tests Insulin Male Metformin Middle Age Norway Power Analysis T-Tests Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: BACKGROUND: Studies have suggested that vitamin D may be important for both insulin sensitivity and insulin secretion, and that supplementation with vitamin D may subsequently prevent development of type 2 diabetes. AIM OF THE STUDY: The objective of the current study was to test the hypothesis that supplementation with vitamin D would improve glycaemic control in subjects with type 2 diabetes. METHODS: Thirty-six subjects with type 2 diabetes, treated with metformin and bed-time insulin, were randomised to supplementation with cholecalciferol (40,000 IU per week) versus placebo for 6 months. Thirty-two subjects participated throughout the entirety of the study. Fasting blood samples were drawn before and at the end of the 6 month study without the previous bed-time insulin injection. The insulin and metformin doses were not changed throughout the study. RESULTS: After 6 months, the fasting glucose, insulin, C-peptide, fructosamine, and HbA(1c) levels were not significantly different from baseline values. In addition, changes in these parameters (values at 6 months minus values at baseline) did not differ between the vitamin D and the placebo group. CONCLUSIONS: We were not able to demonstrate that vitamin D supplementation had a significant effect on glucose metabolism in subjects with type 2 diabetes but without vitamin D deficiency. Further studies are needed in larger groups of subjects with type 2 diabetes or impaired glucose tolerance, who also exhibit low serum 25-hydroxyvitamin D levels. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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