Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity.
OBJECTIVES: (S)-Mephenytoin is selectively metabolised to (S)-4'-hydroxymephenytoin by CYP2C19. The urinary excretion of 4'-hydroxymephenytoin reflects the activity of individual enzymes. We evaluated fractioned urinary collection and beta-glucuronidase pre-treatment in order to determine the optima...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 64; no. 4; pp. 387 - 399 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2008
|
| Acceso en línea: | Ver este registro en EBSCOhost |