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Leukocytapheresis for the treatment of active pouchitis: a pilot study.

Background: Pouchitis is a major long-term complication of ileal pouch-anal anastomosis for ulcerative colitis. The aim of this study is to investigate the efficacy of leukocytapheresis for the treatment of active pouchitis.Methods: Eight patients with active pouchitis received leukocytapheresis wee...

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Publicado en:Journal of Gastroenterology Vol. 43; no. 7; pp. 571 - 576
Autores principales: Araki Y, Mitsuyama K, Nagae T, Tou Y, Nakagawa M, Iwatani Y, Harada M, Ozasa H, Sata M, Noake T, Araki, Yasumi, Mitsuyama, Keiichi, Nagae, Takaaki, Tou, Yuji, Nakagawa, Motonori, Iwatani, Yasue, Harada, Masakazu, Ozasa, Hiroyuki, Sata, Michio, Noake, Toshihiro
Formato: pictorial research tables/charts Journal Article
Publicado: Springer Nature 2008
Acceso en línea:Ver este registro en EBSCOhost
Sumario:Background: Pouchitis is a major long-term complication of ileal pouch-anal anastomosis for ulcerative colitis. The aim of this study is to investigate the efficacy of leukocytapheresis for the treatment of active pouchitis.Methods: Eight patients with active pouchitis received leukocytapheresis weekly for 5 weeks in an open-label treatment protocol together with baseline therapy.Results: Patients showed significant improvement in their pouchitis disease activity index scores, from 9.5 (range, 8-10) to 4.0 (range, 2-8) (P < 0.05). Six (75%) of the 8 treated patients achieved remission. No adverse events were observed.Conclusions: Leukocytapheresis therapy could be a new therapeutic strategy for patients with pouchitis after ileal pouch-anal anastomosis for ulcerative colitis. These encouraging results lead us to propose a randomized controlled trial.