Leukocytapheresis for the treatment of active pouchitis: a pilot study.
Background: Pouchitis is a major long-term complication of ileal pouch-anal anastomosis for ulcerative colitis. The aim of this study is to investigate the efficacy of leukocytapheresis for the treatment of active pouchitis.Methods: Eight patients with active pouchitis received leukocytapheresis wee...
| Publicado en: | Journal of Gastroenterology Vol. 43; no. 7; pp. 571 - 576 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105804406&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105804406 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09441174 EJ7 jtl: Journal of Gastroenterology issn: 09441174 maglogo: N pubinfo: dt: 2008 vid: 43 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105804406 NLM18648745 2009991335 10.1007/s00535-008-2199-0 NLM18648745 105804406 ppf: 571 ppct: 5 formats: tig: atl: Leukocytapheresis for the treatment of active pouchitis: a pilot study. aug: au: Araki Y Mitsuyama K Nagae T Tou Y Nakagawa M Iwatani Y Harada M Ozasa H Sata M Noake T Araki, Yasumi Mitsuyama, Keiichi Nagae, Takaaki Tou, Yuji Nakagawa, Motonori Iwatani, Yasue Harada, Masakazu Ozasa, Hiroyuki Sata, Michio Noake, Toshihiro affil: Kurume Coloproctology Center, Kurume, Japan sug: subj: Colitis, Ulcerative Surgery Leukapheresis Pouchitis Therapy Adult Aged Colitis, Ulcerative Complications Colon Anatomy and Histology Data Analysis Software Drugs, Prescription Equipment and Supplies Female Male Middle Age Pilot Studies Pyoderma Gangrenosum Therapy Wilcoxon Rank Sum Test Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Background: Pouchitis is a major long-term complication of ileal pouch-anal anastomosis for ulcerative colitis. The aim of this study is to investigate the efficacy of leukocytapheresis for the treatment of active pouchitis.Methods: Eight patients with active pouchitis received leukocytapheresis weekly for 5 weeks in an open-label treatment protocol together with baseline therapy.Results: Patients showed significant improvement in their pouchitis disease activity index scores, from 9.5 (range, 8-10) to 4.0 (range, 2-8) (P < 0.05). Six (75%) of the 8 treated patients achieved remission. No adverse events were observed.Conclusions: Leukocytapheresis therapy could be a new therapeutic strategy for patients with pouchitis after ileal pouch-anal anastomosis for ulcerative colitis. These encouraging results lead us to propose a randomized controlled trial. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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