Rheumatoid factor and anti-CCP autoantibodies in rheumatoid arthritis: a review.

For many years, laboratory diagnosis of rheumatoid arthritis has relied on the detection of rheumatoid factor. A new assay that detects antibodies to citrullinated peptides, called the anti-CCP assay, has demonstrated a comparable sensitivity but a much higher specificity than the RF test. This pape...

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Publicado en:Clinical Laboratory Science Vol. 21; no. 1; pp. 15 - 19
Autores principales: Lee AN, Beck CE, Hall M
Formato: Journal Article
Publicado: American Society for Clinical Laboratory Science Winter2008
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Rheumatoid factor and anti-CCP autoantibodies in rheumatoid arthritis: a review.
      aug:
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          Lee AN
          Beck CE
          Hall M
        affil: The University of Southern Mississippi, Hattiesburg, MS
      sug:
        subj:
          Arthritis, Rheumatoid Diagnosis
          Arthritis, Rheumatoid Physiopathology
          Diagnosis, Laboratory Methods
          Autoantibodies Analysis
          Predictive Value of Tests
          Sensitivity and Specificity
      ab: For many years, laboratory diagnosis of rheumatoid arthritis has relied on the detection of rheumatoid factor. A new assay that detects antibodies to citrullinated peptides, called the anti-CCP assay, has demonstrated a comparable sensitivity but a much higher specificity than the RF test. This paper reviews RF and anti-CCP in rheumatoid arthritis and examines the usefulness of each autoantibody in RA testing.
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      doctype: Journal Article
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    language: English
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