Population pharmacokinetics of theophylline in very premature Japanese infants with apnoea.
Objective: To estimate the population pharmacokinetics of theophylline in very premature infants using the non-linear mixed effects modelling. Method: A total of 167 serum concentration measurements obtained from routine theophylline monitoring of 107 very premature Japanese infants were collected....
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 30; no. 6; pp. 591 - 597 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2005
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106089931&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106089931 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Dec2005 vid: 30 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106089931 2009422342 10.1111/j.1365-2710.2005.00689.x NLM16336292 106089931 ppf: 591 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Population pharmacokinetics of theophylline in very premature Japanese infants with apnoea. aug: au: Fukuda T Yukawa E Kondo G Maeda T Shin-O T Kondo Y Imamura T Irikura M Irie T sug: subj: Apnea Drug Therapy Bronchodilator Agents Pharmacokinetics Models, Biological Theophylline Pharmacokinetics Apnea Metabolism Asians Bronchodilator Agents Blood Bronchodilator Agents Therapeutic Use Female Infant, Newborn Infant, Premature Male Reproducibility of Results Retrospective Design Theophylline Blood Theophylline Therapeutic Use Human Infant, Newborn: birth-1 month Female Male ab: Objective: To estimate the population pharmacokinetics of theophylline in very premature infants using the non-linear mixed effects modelling. Method: A total of 167 serum concentration measurements obtained from routine theophylline monitoring of 107 very premature Japanese infants were collected. Results: The final pharmacokinetic parameters were CL (mL/h) = [6·98 · body weight (BW) (kg)2·17 + 0·244 · post-conceptional age (weeks)] · 1·24oxygen support, Vd (L) = 0·492 · BW (kg) and F = 0·660, respectively. Clearance was increased by 24% for patients receiving oxygen support. The inter-individual variabilities in clearance and apparent volume of distribution were 15·6% and 80·4%, respectively, and the residual variability was 34·2% as a coefficient of variation. Conclusion: Application of the findings in this study to patient care may permit selection of an appropriate initial maintenance dosage to achieve target theophylline concentrations, thus enabling the clinician to achieve the desired therapeutic effect in very premature Japanese infants. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|