Traditional home-brewed beer consumption and iron status in patients with esophageal cancer and healthy control subjects from Transkei, South Africa.
Consumption of home-brewed beer is associated with dietary iron excess and a high incidence of esophageal cancer in Transkei, South Africa. We examined the relationship between home-brewed beer consumption and body iron status in 234 patients with esophageal squamous cell carcinoma and 595 control s...
| Publicado en: | Nutrition & Cancer Vol. 56; no. 1; pp. 67 - 74 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2006
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106294371&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106294371 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2006 vid: 56 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106294371 106294371 2009481304 10.1207/s15327914nc5601_9 NLM17176219 106294371 ppf: 67 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Traditional home-brewed beer consumption and iron status in patients with esophageal cancer and healthy control subjects from Transkei, South Africa. aug: au: Matsha T Brink L van Rensburg S Hon D Lombard C Erasmus R affil: Department of Chemical Pathology, University of Stellenbosch Medical School, Tygerberg, 7505, South Africa sug: subj: Alcohol Drinking Alcoholic Beverages Adverse Effects Alcoholic Beverages Classification Carcinoma, Squamous Cell Blood Esophageal Neoplasms Blood Iron Overload Prevention and Control Aged Alcohol Drinking Epidemiology Analysis of Variance Case Control Studies Confidence Intervals Data Analysis Software Esophageal Neoplasms Risk Factors Female Ferric Compounds Blood Funding Source Iron Overload Etiology Iron Overload Familial and Genetic Iron Blood Iron Metabolism Logistic Regression Male Middle Age Nutritional Status Odds Ratio Post Hoc Analysis Questionnaires Random Assignment Relative Risk Sex Factors Smoking South Africa Transferrin Blood Human Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Consumption of home-brewed beer is associated with dietary iron excess and a high incidence of esophageal cancer in Transkei, South Africa. We examined the relationship between home-brewed beer consumption and body iron status in 234 patients with esophageal squamous cell carcinoma and 595 control subjects residing in Transkei. Subjects were screened for iron overload using transferrin saturation >45%, and/or serum ferritin >200 mug/l for women and >300 mug/l for men.Aquestionnairewas administered to all subjects, and iron content of randomly selected home-brewed beer samples was determined. The iron content of home-brewed beer was 258-fold higher than the commercial Castle Lager beer produced by South African Breweries. The prevalence of home-brewed beer consumption was 30.1% in esophageal cancer patients and 15.5% in control subjects and was found not to be a risk factor for esophageal cancer after adjustment for age, sex, and tobacco consumption (male subjects, odds ratio= 1.6 (95% confidence interval [CI]: 0.7-4.5); female subjects, odds ratio=1.7 (95% CI: 0.7-4.5). Iron overload as determined by transferrin saturation and elevated serum ferritin was observed in 4.3% of patients with esophageal cancer and 0.7% of control subjects and was not associated with the consumption of home-brewed beer. Consumption of home-brewed beer is not a risk factor for esophageal cancer and is not linked with iron overload in either cancer patients or control subjects; however, iron overload is likely to result from a combination of dietary intake and a genetic component. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|