The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure.
Background: Despite its high prevalence, optimal therapy for diastolic heart failure (DHF) has not been determined. Alagebrium chloride (ALT-711) is a novel compound that breaks glucose crosslinks and may improve ventricular and arterial compliance.Methods and Results: A total of 23 patients, mean a...
| Publicado en: | Journal of Cardiac Failure Vol. 11; no. 3; pp. 191 - 196 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
W B Saunders
2005 Apr
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106417228&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106417228 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10719164 DOP jtl: Journal of Cardiac Failure issn: 10719164 maglogo: N pubinfo: dt: 2005 Apr vid: 11 iid: 3 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 106417228 106417228 NLM15812746 2009130270 NLM15812746 106417228 ppf: 191 ppct: 5 formats: tig: atl: The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure. aug: au: Little WC Zile MR Kitzman DW Hundley WG O'Brien TX Degroof RC Little, William C Zile, Michael R Kitzman, Dalane W Hundley, W Gregory O'Brien, Terrence X Degroof, Robert C affil: Department of Internal Medicine, Cardiology Section, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, USA sug: subj: Cardiotonic Agents Therapeutic Use Diastole Glucose Drug Effects Heart Failure Drug Therapy Aged Clinical Assessment Tools Data Analysis, Statistical Descriptive Statistics Female Funding Source Health Status Indicators Heart Atrium Drug Effects Heart Ventricle Drug Effects Magnetic Resonance Imaging Male New Jersey Nonexperimental Studies North Carolina Prospective Studies Questionnaires South Carolina Human Aged: 65+ years Female Male ab: Background: Despite its high prevalence, optimal therapy for diastolic heart failure (DHF) has not been determined. Alagebrium chloride (ALT-711) is a novel compound that breaks glucose crosslinks and may improve ventricular and arterial compliance.Methods and Results: A total of 23 patients, mean age 71 years, with stable DHF, ejection fraction (EF) >50%, were enrolled in a 16-week, open-label trial of alagebrium 420 mg per day. Assessments included: peak exercise oxygen consumption, aortic distensibility, and left ventricular EF and mass by magnetic resonance imaging, Doppler diastolic filling, and quality of life by the Minnesota Living with Heart Failure questionnaire. One patient discontinued treatment because of a myocardial infarction after 12 days of treatment, and a second died suddenly after 10 weeks of treatment. Thus 21 patients completed the study. Left ventricular mass was 124 +/- 35 g at baseline and decreased to 119 +/- 34 g at follow up ( P = .036). This was accompanied by a decrease in the ratio of Doppler early diastolic flow velocity to Doppler early diastolic mitral annulus velocity (E') from 10.6 +/- 2.7 to 9.4 +/- 1.9 ( P = .076) and an increase in E' from 7.3 +/- 1.2 to 8.4 +/- 1.7 cm/s ( P = .045). The Minnesota Living with Heart Failure total score improved from 41 +/- 21 to 32 +/- 21 ( P = .01). There were no changes in EF (64 +/- 4% at baseline), blood pressure, peak exercise oxygen consumption, and aortic distensibility.Conclusion: Sixteen weeks of treatment with the glucose crosslink breaker, alagebrium, resulted in a decrease in left ventricular mass and improvements in left ventricular diastolic filling and quality of life in patient with DHF. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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