Hormonal response to diets high in soy or animal protein without and with isoflavones in moderately hypercholesterolemic subjects.
Consumption of soy protein has been associated with altered risk of developing endocrine-regulated cancers. This study was designed to assess the independent effect of soy relative to animal protein and soy-derived isoflavones on circulating estrogen and androgen concentrations in postmenopausal wom...
| Published in: | Nutrition & Cancer Vol. 51; no. 1; pp. 1 - 7 |
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| Main Authors: | , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
2005
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106502600&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106502600 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2005 vid: 51 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106502600 106502600 2005122234 10.1207/s15327914nc5101_1 NLM15749623 106502600 ppf: 1 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Hormonal response to diets high in soy or animal protein without and with isoflavones in moderately hypercholesterolemic subjects. aug: au: Goldin BR Brauner E Adlercreutz H Ausman LM Lichtenstein AH affil: Department of Family Medicine and Community Medicine, Tufts University School of Medicine, Boston, MA 02111 sug: subj: Diet Hypercholesterolemia Prevention and Control Meat Phytochemicals Sex Hormones Blood Soy Proteins Analysis of Variance Androgens Androgens Blood Comparative Studies Descriptive Statistics Estrogens Estrogens Blood Experimental Studies Female Fluoroimmunoassay Funding Source Male Middle Age Neoplasms Prevention and Control Postmenopause Human Middle Aged: 45-64 years Female Male ab: Consumption of soy protein has been associated with altered risk of developing endocrine-regulated cancers. This study was designed to assess the independent effect of soy relative to animal protein and soy-derived isoflavones on circulating estrogen and androgen concentrations in postmenopausal women and older men. Forty-two subjects (> 50 yr) with low-density lipoprotein cholesterol levels of > or = 3.36 mmol/l were fed each of 4 diets in randomized order for 6 wk/phase. All food and drink were provided. Diets contained 25 g soy or common sources of animal protein/4.2 MJ containing trace or 50 mg isoflavones/4.2 MJ. At the end of each diet phase, concentrations of estrone sulfate, estrone, estradiol, testosterone, androstendione, dihydrotestosterone, dehydroepiandrosterone, and dehydroepiandrosterone sulfate were measured. In postmenopausal women, concentrations of estrone were higher and its precursor, dehydroepiandrosterone, lower after consuming the soy compared with animal protein diets (P = 0.0396 and 0.0374, respectively). There was no significant effect of isoflavones on any of the hormones measured. In older men, dehydroepiandrosterone sulfate concentrations were lower after consuming the isoflavone (P = 0.0106) and higher after soy, compared with the animal protein diets (P = 0.0118). These data suggest that relatively large amounts of soy protein or soy-derived isoflavones had modest and limited sex-specific effects on circulating hormone levels. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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