Dietary antioxidants, supplements, and risk of epithelial ovarian cancer.
Several studies of dietary and serum antioxidant micronutrients (vitamins A, C, and E and beta-carotene) suggest that higher levels may be protective for ovarian cancer. None of these has examined supplements. We used a food frequency questionnaire and additional questions on supplements to study 16...
| Publicado en: | Nutrition & Cancer Vol. 40; no. 2; pp. 92 - 99 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2001
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106922014&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106922014 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2001 vid: 40 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106922014 106922014 2002053002 10.1207/s15327914nc402_3 NLM11962261 106922014 ppf: 92 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Dietary antioxidants, supplements, and risk of epithelial ovarian cancer. aug: au: Fleischauer AT Olson SH Mignone L Simonsen N Caputo TA Harlap S affil: Dept of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 sug: subj: Antioxidants Diet Ovarian Neoplasms Risk Factors Adult Aged Ascorbic Acid beta Carotene Case Control Studies Confidence Intervals Dietary Supplementation Female Interviews Logistic Regression Middle Age New York Odds Ratio Questionnaires Selenium T-Tests Vitamin A Vitamin E Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female ab: Several studies of dietary and serum antioxidant micronutrients (vitamins A, C, and E and beta-carotene) suggest that higher levels may be protective for ovarian cancer. None of these has examined supplements. We used a food frequency questionnaire and additional questions on supplements to study 168 histologically confirmed epithelial ovarian cancer cases, 159 community controls, and 92 hospital-based controls. Antioxidant consumption from diet or supplements was calculated in milligrams or international units per day. In multivariate analyses using only community controls, the highest levels of intake of vitamins C and E from supplements were protective: odds ratio (OR) = 0.40 [95% confidence interval (CI) = 0.21-0.78] and OR = 0.33 (95% CI = 0.18-0.60), respectively. Consumption of antioxidants from diet was unrelated to risk. In analyses combining antioxidant intake from diet and supplements, vitamins C (> 363 mg/day) and E (> 75 mg/day) were associated with reduced risks: OR = 0.45 (95% CI = 0.22-0.91) and OR = 0.44 (95% CI = 0.21-0.94), respectively. Results were similar, with some attenuation toward the null, in analyses combining both control groups. The levels of vitamins C and E associated with the protective effect were well above the current US Recommended Dietary Allowances. These findings support the hypothesis that antioxidant vitamins C and E from supplements are related to a reduced risk of ovarian cancer. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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