Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner.
Purpose: To test the hypothesis that the joint distribution of x-ray transmission and dark-field signals obtained with a compact cone-beam preclinical scanner with a polychromatic source can be used to diagnose pulmonary emphysema in ex vivo murine lungs.Materials and Methods: The animal care commit...
| Publicado en: | Radiology Vol. 269; no. 2; pp. 427 - 434 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wolters Kluwer Health
2013 Nov
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107916185&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107916185 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00338419 0IQ jtl: Radiology issn: 00338419 maglogo: N pubinfo: dt: 2013 Nov vid: 269 iid: 2 pid: 79357 pub: Wolters Kluwer Health place: New York, New York artinfo: ui: 107916185 107916185 NLM23696682 2012346476 10.1148/radiol.13122413 NLM23696682 107916185 ppf: 427 ppct: 7 formats: tig: atl: Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner. aug: au: Yaroshenko, Andre Meinel, Felix G Bech, Martin Tapfer, Arne Velroyen, Astrid Schleede, Simone Auweter, Sigrid Bohla, Alexander Yildirim, Ali Ö Nikolaou, Konstantin Bamberg, Fabian Eickelberg, Oliver Reiser, Maximilian F Pfeiffer, Franz affil: Department of Physics and Institute of Medical Engineering, Technische Universität München, James-Franck-Strasse 1, 85748 Garching, Germany; Institute of Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munich and Ludwig-Maximilians-University Hospital Munich, Neuherberg, Germany. sug: subj: Pulmonary Emphysema Radiography Tomography, X-Ray Computed Methods Animals Equipment Design Female Mice Radiographic Image Interpretation, Computer-Assisted Tomography, X-Ray Computed Equipment and Supplies Female ab: Purpose: To test the hypothesis that the joint distribution of x-ray transmission and dark-field signals obtained with a compact cone-beam preclinical scanner with a polychromatic source can be used to diagnose pulmonary emphysema in ex vivo murine lungs.Materials and Methods: The animal care committee approved this study. Three excised murine lungs with pulmonary emphysema and three excised murine control lungs were imaged ex vivo by using a grating-based micro-computed tomographic (CT) scanner. To evaluate the diagnostic value, the natural logarithm of relative transmission and the natural logarithm of dark-field scatter signal were plotted on a per-pixel basis on a scatterplot. Probability density function was fit to the joint distribution by using principle component analysis. An emphysema map was calculated based on the fitted probability density function.Results: The two-dimensional scatterplot showed a characteristic difference between control and emphysematous lungs. Control lungs had lower average median logarithmic transmission (-0.29 vs -0.18, P = .1) and lower average dark-field signal (-0.54 vs -0.37, P = .1) than emphysematous lungs. The angle to the vertical axis of the fitted regions also varied significantly (7.8° for control lungs vs 15.9° for emphysematous lungs). The calculated emphysema distribution map showed good agreement with histologic findings.Conclusion: X-ray dark-field scatter images of murine lungs obtained with a preclinical scanner can be used in the diagnosis of pulmonary emphysema.Supplemental Material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.13122413/-/DC1. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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