Differentially Addressable Cavities within Metal-Organic Cage-Cross-Linked Polymeric Hydrogels.

Here we report a new class of hydrogels formed by polymers that are cross-linked through subcomponent self-assembled metal-organic cages. Selective encapsulation of guest molecules within the cages creates two distinct internal phases within the hydrogel, which allows for contrasting release profile...

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Detalles Bibliográficos
Publicado en:	Journal of the American Chemical Society Vol. 137; no. 30; pp. 9722 - 9730
Autores principales:	Foster, Jonathan A., Parker, Richard M., Belenguer, Ana M., Norifumi Kishi, Sutton, Sam, Abell, Chris, Nitschke, Jonathan R.
Formato:	Artículo
Publicado:	American Chemical Society 8/5/2015
Materias:	Hydrogels Metal-organic frameworks Polymer colloids Structural frames Aldehydes
Acceso en línea:	Ver este registro en EBSCOhost

Descripción
Sumario:	Here we report a new class of hydrogels formed by polymers that are cross-linked through subcomponent self-assembled metal-organic cages. Selective encapsulation of guest molecules within the cages creates two distinct internal phases within the hydrogel, which allows for contrasting release profiles of related molecules depending on their aptitude for encapsulation within the cages. The hydrogels were fabricated into microparticles via a droplet-based microfluidic approach and proved responsive to a variety of stimuli, including acid and competing amine or aldehyde subcomponents, allowing for the triggered release of cargo.